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KMID : 1134820000290061133
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 6 p.1133 ~ p.1138
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Immunosuppressive Effects of Herbal Plant Extracts on Alloantigen Reactive Cell Proliferation and Cytotoxicity
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Jeong Young-Ran
Ha Mee-Hye
Kim Seong-Ho
Jo Sung-Kee
Byun Myung-Woo
Cho Hyun-Wook
Seo Kwon-Il
Lee Sung-Tae
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Abstract
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In this experiment, we showed the immunosuppressive effects of herbal plant extracts on the alloantigen reactive proliferation and cytotoxicity. The extracts of Angelica gigas, Crataegus pinnatifida, Houttuynia cordata, Acanthopanax sessiliflorum and Astragalus membranaceus markedly suppressed on the pro- liferation of primary T cells stimulated with allogeneic spleen cells in a dose-dependent manner. The production of IL-2, IFN-γ, IL-4 and IL-10 in the alloreactive primary T cells showed no significant difference in the presence or absence of herbal plants extracts. Also the result of mixed lymphocyte reaction (MLR)-induced cytotoxic T lymphocyte (CTL) showed what is above a certain point 50% inhibition. Specially, the extracts of Acanthopanax sessiliflorum and Astragalus membranaceus com- pletely suppressed the killing activity of CTL. Theses results suggest that the extracts of 5 herbal plants can be used as immunosuppressive agents.
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KEYWORD
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alloantigen, herbal plants, immunosuppression, T cells, crytotoxicity
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